Stat2 - signal transducer and activator of transcription 2

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and type I interferon signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2). [provided by Alliance of Genome Resources, Apr 2022]