Serpine2 - serine (or cysteine) peptidase inhibitor, clade E, member 2

Enables serine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in negative regulation of plasminogen activation and negative regulation of platelet aggregation. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and negative regulation of signal transduction. Located in extracellular region and neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; limb; musculoskeletal system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2). [provided by Alliance of Genome Resources, Apr 2022]