Sox4 - SRY (sex determining region Y)-box 4

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and miRNA binding activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of cell communication. Acts upstream of or within endocrine pancreas development; hematopoietic stem cell homeostasis; and somatic stem cell population maintenance. Located in nucleus. Part of transcription regulator complex. Is active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder cancer. Orthologous to human SOX4 (SRY-box transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]