Sox1 - SRY (sex determining region Y)-box 1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in interneuron migration; regulation of oligodendrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor; generation of neurons; and lens morphogenesis in camera-type eye. Located in nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; large intestine; and neural ectoderm. Orthologous to human SOX1 (SRY-box transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]