Sorl1 - sortilin-related receptor, LDLR class A repeats-containing

Predicted to enable several functions, including low-density lipoprotein particle binding activity; peptide binding activity; and small GTPase binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of protein metabolic process; and regulation of signal transduction. Located in extracellular space; nuclear envelope lumen; and perinucleolar compartment. Is integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Apr 2022]