Snai1 - snail family zinc finger 1

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of epithelial to mesenchymal transition; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; left/right pattern formation; and negative regulation of cell differentiation involved in embryonic placenta development. Located in cytoplasm; nucleus; and pericentric heterochromatin. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy and skin cancer. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]