Smarcb1 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Predicted to enable several functions, including Tat protein binding activity; p53 binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Acts upstream of or within blastocyst hatching; cell differentiation; and negative regulation of cell population proliferation. Located in XY body and nucleus. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb primordium; and sensory organ. Used to study atypical teratoid rhabdoid tumor. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; atypical teratoid rhabdoid tumor; neurilemmomatosis; and rhabdoid cancer. Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Apr 2022]