Slit3 - slit guidance ligand 3

Predicted to enable Roundabout binding activity and heparin binding activity. Involved in aortic valve morphogenesis; atrioventricular valve morphogenesis; and ventricular septum morphogenesis. Acts upstream of or within several processes, including axon guidance; negative regulation of cell population proliferation; and negative regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Used to study congenital diaphragmatic hernia. Orthologous to human SLIT3 (slit guidance ligand 3). [provided by Alliance of Genome Resources, Apr 2022]