Slc1a3 - solute carrier family 1 (glial high affinity glutamate transporter), member 3

Enables glutamate binding activity and high-affinity glutamate transmembrane transporter activity. Involved in D-aspartate import across plasma membrane and cellular response to cocaine. Acts upstream of or within several processes, including L-glutamate import across plasma membrane; gamma-aminobutyric acid biosynthetic process; and nervous system development. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including brain; connective tissue; eye; genitourinary system; and spinal cord. Used to study low tension glaucoma. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Apr 2022]