Slc1a2 - solute carrier family 1 (glial high affinity glutamate transporter), member 2

Enables cysteine transmembrane transporter activity and high-affinity glutamate transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; positive regulation of glucose import; and visual behavior. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is integral component of plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]