Slc1a1 - solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Enables anion transmembrane transporter activity and identical protein binding activity. Involved in several processes, including cation transmembrane transport; learning or memory; and response to alkaloid. Acts upstream of or within several processes, including behavioral fear response; ion homeostasis; and regulation of cellular protein metabolic process. Located in several cellular components, including apical plasma membrane; endosome membrane; and membrane raft. Is integral component of plasma membrane. Is active in cytoplasm and dendrite. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Used to study dicarboxylic aminoaciduria and low tension glaucoma. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Apr 2022]