Six3 - sine oculis-related homeobox 3

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; lens fiber cell apoptotic process; and neuroblast migration. Acts upstream of or within several processes, including animal organ development; circadian behavior; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including embryo ectoderm; limb; maxillary process; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]