Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic morphogenesis; kidney development; and positive regulation of chondrocyte proliferation. Acts upstream of or within several processes, including animal organ development; condensed mesenchymal cell proliferation; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human SIX2 (SIX homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]