Shox2 - short stature homeobox 2

Enables sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of cell development; and regulation of branching morphogenesis of a nerve. Acts upstream of or within several processes, including animal organ development; embryonic forelimb morphogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; facial prominence; genitourinary system; heart; and limb mesenchyme. Used to study Leri-Weill dyschondrosteosis. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human SHOX2 (short stature homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]