Sorbs3 - sorbin and SH3 domain containing 3

Predicted to enable vinculin binding activity. Acts upstream of or within cell-substrate adhesion; negative regulation of transcription by RNA polymerase II; and positive regulation of MAPK cascade. Located in cytoplasm; focal adhesion; and nucleus. Is expressed in several structures, including branchial arch; eye; gonad; heart; and hindbrain. Orthologous to human SORBS3 (sorbin and SH3 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]