Sh3gl1 - SH3-domain GRB2-like 1

Predicted to enable several functions, including SH3 domain binding activity; beta-1 adrenergic receptor binding activity; and enzyme binding activity. Involved in synaptic vesicle uncoating. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in several structures, including central nervous system; chondrocranium; liver; spleen; and testis. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Apr 2022]