Frzb - frizzled-related protein

Enables Wnt-protein binding activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cartilage development; and negative regulation of cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein). [provided by Alliance of Genome Resources, Apr 2022]