Sema7a - sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

Enables integrin binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Acts upstream of or within nervous system development and positive regulation of protein phosphorylation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human SEMA7A (semaphorin 7A (John Milton Hagen blood group)). [provided by Alliance of Genome Resources, Apr 2022]