Nptn - neuroplastin

Predicted to enable cell-cell adhesion mediator activity; transmembrane transporter binding activity; and type 1 fibroblast growth factor receptor binding activity. Involved in cellular calcium ion homeostasis and negative regulation of cytokine production. Acts upstream of or within excitatory synapse assembly; modulation of chemical synaptic transmission; and regulation of receptor localization to synapse. Located in dendrite and immunological synapse. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and respiratory system. Orthologous to human NPTN (neuroplastin). [provided by Alliance of Genome Resources, Apr 2022]