Scnn1b - sodium channel, nonvoltage-gated 1 beta

Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium channel activity. Acts upstream of or within several processes, including cellular response to aldosterone; leukocyte activation involved in inflammatory response; and monovalent inorganic cation homeostasis. Located in external side of plasma membrane. Is integral component of membrane. Part of plasma membrane protein complex and sodium channel complex. Is expressed in several structures, including aorta; endocrine gland; genitourinary system; lung; and stomach. Used to study Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; and cystic fibrosis. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]