Scn9a - sodium channel, voltage-gated, type IX, alpha

Predicted to enable sodium ion binding activity and voltage-gated sodium channel activity. Acts upstream of or within several processes, including behavioral response to pain; inflammatory response; and response to toxic substance. Predicted to be integral component of plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in several structures, including alimentary system; brain; immune system; male reproductive gland or organ; and respiratory system epithelium. Human ortholog(s) of this gene implicated in erythromelalgia; generalized epilepsy with febrile seizures plus 7; and paroxysmal extreme pain disorder. Orthologous to human SCN9A (sodium voltage-gated channel alpha subunit 9). [provided by Alliance of Genome Resources, Apr 2022]