Hps6 - HPS6, biogenesis of lysosomal organelles complex 2 subunit 3

Predicted to enable GTP-dependent protein binding activity and small GTPase binding activity. Involved in lipid homeostasis; lysosome localization; and protein secretion. Acts upstream of or within blood coagulation; melanocyte differentiation; and organelle organization. Predicted to be located in several cellular components, including endoplasmic reticulum; endosome; and lysosome. Predicted to be part of BLOC-2 complex. Predicted to be active in lysosomal membrane. Used to study Hermansky-Pudlak syndrome 6. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome and Hermansky-Pudlak syndrome 6. Orthologous to human HPS6 (HPS6 biogenesis of lysosomal organelles complex 2 subunit 3). [provided by Alliance of Genome Resources, Apr 2022]