Polr1b - polymerase (RNA) I polypeptide B

Predicted to enable several functions, including DNA binding activity; metal ion binding activity; and ribonucleoside binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Acts upstream of or within embryo implantation; nucleologenesis; and rRNA transcription. Located in chromosome and nucleolus. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Orthologous to human POLR1B (RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Apr 2022]