Rorc - RAR-related orphan receptor gamma

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription coactivator binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of thymocyte apoptotic process; and regulation of gene expression. Acts upstream of or within hematopoietic or lymphoid organ development; protein phosphorylation; and regulation of gamma-delta T cell differentiation. Located in external side of plasma membrane and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; sensory organ; and thyroid gland. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Apr 2022]