Robo1 - roundabout guidance receptor 1

Predicted to enable LRR domain binding activity; axon guidance receptor activity; and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and regulation of gene expression. Acts upstream of or within animal organ development; axon guidance; and negative regulation of cell population proliferation. Located in axolemma. Is expressed in several structures, including central nervous system; foot; genitourinary system; jaw; and sensory organ. Used to study cystic kidney disease and lung cancer. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Apr 2022]