Rfc1 - replication factor C (activator 1) 1

Predicted to enable DNA binding activity; DNA clamp unloader activity; and protein domain specific binding activity. Predicted to be involved in DNA clamp unloading; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in West Nile fever. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Apr 2022]