Rasgrp1 - RAS guanyl releasing protein 1

Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Involved in positive regulation of T cell differentiation in thymus and positive regulation of natural killer cell differentiation. Acts upstream of or within several processes, including activation of GTPase activity; mast cell degranulation; and regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Is expressed in brain; olfactory epithelium; olfactory lobe; and telencephalon mantle layer. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1). [provided by Alliance of Genome Resources, Apr 2022]