Pirt - phosphoinositide-interacting regulator of transient receptor potential channels

Enables phosphatidylinositol bisphosphate binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including behavioral response to pain; phosphatidylinositol-mediated signaling; and positive regulation of cation channel activity. Located in plasma membrane. Is expressed in gut; nervous system; and olfactory epithelium. Orthologous to human PIRT (phosphoinositide interacting regulator of transient receptor potential channels). [provided by Alliance of Genome Resources, Apr 2022]