Ptprn - protein tyrosine phosphatase, receptor type, N

Predicted to enable GTPase binding activity; spectrin binding activity; and ubiquitin-like protein ligase binding activity. Involved in insulin secretion involved in cellular response to glucose stimulus; luteinization; and positive regulation of type B pancreatic cell proliferation. Predicted to be located in several cellular components, including axon terminus; neuronal cell body; and secretory granule. Predicted to colocalize with Golgi apparatus; endosome; and plasma membrane. Is expressed in lens vesicle and nervous system. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N). [provided by Alliance of Genome Resources, Apr 2022]