Ptprj - protein tyrosine phosphatase, receptor type, J

Enables protein tyrosine phosphatase activity. Involved in several processes, including regulation of cell migration; regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Located in immunological synapse and ruffle membrane. Is expressed in midbrain; renal calyx; renal pelvis; and superior colliculus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J). [provided by Alliance of Genome Resources, Apr 2022]