Ptpra - protein tyrosine phosphatase, receptor type, A

Enables protein tyrosine phosphatase activity. Involved in integrin-mediated signaling pathway; modulation of chemical synaptic transmission; and regulation of focal adhesion assembly. Acts upstream of or within insulin receptor signaling pathway and protein phosphorylation. Located in focal adhesion and membrane. Is active in Schaffer collateral - CA1 synapse. Is integral component of synaptic membrane. Is expressed in several structures, including adrenal gland; central nervous system; decidua; extraembryonic component; and future brain. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A). [provided by Alliance of Genome Resources, Apr 2022]