Ptpn1 - protein tyrosine phosphatase, non-receptor type 1

Predicted to enable several functions, including protein phosphatase 2A binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; negative regulation of signal transduction; and peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Acts upstream of or within insulin receptor signaling pathway and protein dephosphorylation. Located in early endosome and sorting endosome. Is expressed in central nervous system; midbrain; and superior colliculus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]