Nos1ap - nitric oxide synthase 1 adaptor protein

Enables PDZ domain binding activity; nitric-oxide synthase binding activity; and protease binding activity. Involved in several processes, including neuron projection regeneration; positive regulation of peptidyl-cysteine S-nitrosylation; and regulation of calcium ion transmembrane transport. Located in cytosol and nucleus. Is active in glutamatergic synapse; postsynapse; and presynapse. Colocalizes with nuclear membrane. Used to study mental depression. Biomarker of congestive heart failure and sciatic neuropathy. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]