Ptk2b - PTK2 protein tyrosine kinase 2 beta

Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including regulation of cell migration; regulation of intracellular signal transduction; and regulation of phosphate metabolic process. Acts upstream of or within cellular response to fluid shear stress and protein phosphorylation. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and heart. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]