Ptgis - prostaglandin I2 (prostacyclin) synthase

Predicted to enable heme binding activity and prostaglandin-I synthase activity. Acts upstream of or within decidualization and embryo implantation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; ear; early embryo; and genitourinary system. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, Apr 2022]