Prss12 - protease, serine 12 neurotrypsin (motopsin)

Enables serine-type endopeptidase activity. Involved in exocytosis. Acts upstream of or within zymogen activation. Located in several cellular components, including dendrite; synaptic cleft; and terminal bouton. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Apr 2022]