Pole - polymerase (DNA directed), epsilon

Predicted to enable DNA binding activity; catalytic activity, acting on DNA; and chromatin binding activity. Predicted to be involved in DNA metabolic process and G1/S transition of mitotic cell cycle. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of epsilon DNA polymerase complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]