Polb - polymerase (DNA directed), beta

Predicted to enable several functions, including DNA-directed DNA polymerase activity; damaged DNA binding activity; and microtubule binding activity. Acts upstream of or within several processes, including base-excision repair, gap-filling; immune system development; and intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm and spindle microtubule. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in early conceptus; hemolymphoid system; muscle tissue; nervous system; and sensory organ. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human POLB (DNA polymerase beta). [provided by Alliance of Genome Resources, Apr 2022]