Pkd2 - polycystin 2, transient receptor potential cation channel

Enables several functions, including ATPase binding activity; cation channel activity; and identical protein binding activity. Involved in several processes, including detection of nodal flow; inorganic cation transmembrane transport; and placenta development. Acts upstream of or within several processes, including animal organ development; negative regulation of ryanodine-sensitive calcium-release channel activity; and receptor signaling pathway via JAK-STAT. Located in several cellular components, including basal cortex; ciliary membrane; and microtubule cytoskeleton. Part of polycystin complex. Colocalizes with cell-cell junction. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; early conceptus; and genitourinary system. Used to study autosomal dominant polycystic kidney disease and polycystic kidney disease 2. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2 (polycystin 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Apr 2022]