Pou1f1 - POU domain, class 1, transcription factor 1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; positive regulation of cellular biosynthetic process; and somatotropin secreting cell development. Located in nucleus. Is expressed in several structures, including eye; genitourinary system; pituitary gland; and trunk somite. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]