Pik3ca - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Enables 1-phosphatidylinositol-3-kinase activity; insulin receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of peptidyl-serine phosphorylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including energy homeostasis; negative regulation of apoptotic process; and protein kinase B signaling. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]