Pfn2 - profilin 2

Predicted to enable ATP hydrolysis activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including modification of postsynaptic actin cytoskeleton; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Acts upstream of or within negative regulation of actin filament polymerization and positive regulation of actin filament polymerization. Located in glutamatergic synapse; postsynapse; and terminal bouton. Is active in Schaffer collateral - CA1 synapse and presynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). [provided by Alliance of Genome Resources, Apr 2022]