Pdx1 - pancreatic and duodenal homeobox 1

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pancreas development; and regulation of transcription by RNA polymerase II. Located in nuclear speck. Is expressed in several structures, including gut; liver and biliary system; reproductive system; sensory organ; and skeleton. Used to study maturity-onset diabetes of the young; maturity-onset diabetes of the young type 4; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]