Pdpk1 - 3-phosphoinositide dependent protein kinase 1

Enables 3-phosphoinositide-dependent protein kinase activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; regulation of mast cell degranulation; and type B pancreatic cell development. Acts upstream of or within hyperosmotic response. Located in cytoplasmic vesicle and postsynaptic density. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]