Bloc1s6 - biogenesis of lysosomal organelles complex-1, subunit 6, pallidin

Predicted to enable actin filament binding activity and protein homodimerization activity. Involved in several processes, including cellular amino acid metabolic process; limbic system development; and vesicle organization. Acts upstream of or within several processes, including melanocyte differentiation; positive regulation of natural killer cell activation; and secretion of lysosomal enzymes. Located in ciliary basal body and endosome. Part of BLOC-1 complex. Is expressed in brain; spinal cord; and thoracic ganglion. Used to study Hermansky-Pudlak syndrome 9; platelet storage pool deficiency; and pulmonary emphysema. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome 9. Orthologous to human BLOC1S6 (biogenesis of lysosomal organelles complex 1 subunit 6). [provided by Alliance of Genome Resources, Apr 2022]