Ddr2 - discoidin domain receptor family, member 2

Enables collagen binding activity and protein tyrosine kinase collagen receptor activity. Involved in several processes, including chondrocyte proliferation; collagen fibril organization; and collagen-activated tyrosine kinase receptor signaling pathway. Acts upstream of or within positive regulation of cell population proliferation; protein autophosphorylation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in actin cytoskeleton and apical plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in alimentary system; central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (discoidin domain receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]