Enables DNA N-glycosylase activity and DNA-(apurinic or apyrimidinic site) endonuclease activity. Involved in nucleotide-excision repair, DNA incision, 5'-to lesion. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis 3. Orthologous to human NTHL1 (nth like DNA glycosylase 1). [provided by Alliance of Genome Resources, Apr 2022]