Nrp1 - neuropilin 1

Enables protein kinase binding activity; transmembrane signaling receptor activity; and vascular endothelial growth factor binding activity. Involved in several processes, including nervous system development; regulation of signal transduction; and vasculature development. Acts upstream of or within several processes, including morphogenesis of a branching epithelium; nervous system development; and toxin transport. Located in several cellular components, including endosome; focal adhesion; and neurofilament. Is integral component of postsynaptic membrane. Is expressed in several structures, including cardiovascular system; jaw; lung; nervous system; and sensory organ. Used to study retinal vein occlusion. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Apr 2022]