Slc11a1 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Alias:
Bcg
Ity
Lsh
ity
Ity1
Nramp
Nramp1
Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
Enables manganese ion transmembrane transporter activity. Involved in metal ion export. Acts upstream of or within several processes, including cation homeostasis; defense response to other organism; and positive regulation of macromolecule metabolic process. Located in cytoplasmic vesicle and lysosome. Is expressed in several structures, including brain; gut; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Buruli ulcer disease; autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1). [provided by Alliance of Genome Resources, Apr 2022]