Uhrf1 - ubiquitin-like, containing PHD and RING finger domains, 1

Enables several functions, including hemi-methylated DNA-binding activity; histone binding activity; and ubiquitin protein ligase activity. Involved in maintenance of DNA methylation; negative regulation of transcription by RNA polymerase II; and protein ubiquitination. Located in heterochromatin; nuclear matrix; and replication fork. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb phalanx; and sensory organ. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1). [provided by Alliance of Genome Resources, Apr 2022]